/* ==========================================================================
   GENOMA HUMANO INTERACTIVO - DESIGN SYSTEM & STYLESHEET
   ========================================================================== */

/* Variables & Themes */
:root {
    /* Colors - Dark Theme (Default) */
    --bg-primary: #0a0e17;
    --bg-secondary: #131a26;
    --bg-tertiary: #1b2536;
    --border-color: rgba(255, 255, 255, 0.08);
    --border-hover: rgba(0, 242, 254, 0.3);
    
    --text-primary: #f1f5f9;
    --text-secondary: #94a3b8;
    --text-muted: #64748b;
    
    /* Brand & DNA Accent Colors */
    --accent-cyan: #00f2fe;
    --accent-purple: #9d4edd;
    --accent-purple-glow: rgba(157, 78, 221, 0.15);
    --accent-cyan-glow: rgba(0, 242, 254, 0.15);
    
    /* Nitrogenous Bases Colors */
    --color-adenine: #3a86f0;      /* Modern Blue */
    --color-thymine: #ffbe0b;       /* Golden Yellow */
    --color-guanine: #ff006e;       /* Vibrant Coral/Red */
    --color-cytosine: #06d6a0;      /* Emerald Green */
    --color-backbone: #8338ec;      /* Royal Purple */
    --color-hydrogen: rgba(255, 255, 255, 0.25);
    
    /* Helper classes */
    --success: #10b981;
    --warning: #f59e0b;
    --danger: #ef4444;
    
    /* Typography */
    --font-heading: 'Outfit', sans-serif;
    --font-body: 'Space Grotesk', sans-serif;
    
    /* Transitions */
    --transition-fast: 0.2s ease;
    --transition-normal: 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    --transition-slow: 0.6s cubic-bezier(0.4, 0, 0.2, 1);
    
    /* Shadows & Blur */
    --glass-blur: 16px;
    --card-shadow: 0 8px 32px 0 rgba(0, 0, 0, 0.37);
    --glow-shadow: 0 0 20px rgba(0, 242, 254, 0.2);
}

/* Light Theme overrides */
body.light-mode {
    --bg-primary: #f8fafc;
    --bg-secondary: #ffffff;
    --bg-tertiary: #f1f5f9;
    --border-color: rgba(0, 0, 0, 0.08);
    --border-hover: rgba(157, 78, 221, 0.3);
    
    --text-primary: #0f172a;
    --text-secondary: #475569;
    --text-muted: #94a3b8;
    
    --accent-cyan: #0284c7;
    --accent-purple: #7c3aed;
    --accent-purple-glow: rgba(124, 58, 237, 0.08);
    --accent-cyan-glow: rgba(2, 132, 199, 0.08);
    
    --color-hydrogen: rgba(15, 23, 42, 0.2);
    --card-shadow: 0 8px 32px 0 rgba(0, 0, 0, 0.08);
}

/* Global Reset & Base Styles */
* {
    box-sizing: border-box;
    margin: 0;
    padding: 0;
}

body {
    background-color: var(--bg-primary);
    color: var(--text-primary);
    font-family: var(--font-body);
    min-height: 100vh;
    display: flex;
    flex-direction: column;
    overflow-x: hidden;
    transition: background-color var(--transition-normal), color var(--transition-normal);
}

/* Background Grids & Ambient Glow */
.grid-bg {
    position: fixed;
    top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    background-image: 
        radial-gradient(var(--border-color) 1px, transparent 1px),
        radial-gradient(var(--border-color) 1px, transparent 1px);
    background-size: 40px 40px;
    background-position: 0 0, 20px 20px;
    opacity: 0.4;
    z-index: -2;
    pointer-events: none;
}

.glow-effect {
    position: fixed;
    width: 600px;
    height: 600px;
    border-radius: 50%;
    filter: blur(140px);
    opacity: 0.12;
    z-index: -1;
    pointer-events: none;
    transition: opacity var(--transition-slow);
}

.glow-cyan {
    top: -200px;
    right: -100px;
    background: radial-gradient(circle, var(--accent-cyan) 0%, transparent 70%);
}

.glow-purple {
    bottom: -200px;
    left: -100px;
    background: radial-gradient(circle, var(--accent-purple) 0%, transparent 70%);
}

/* Typography elements */
h1, h2, h3, h4, h5, h6 {
    font-family: var(--font-heading);
    font-weight: 600;
    letter-spacing: -0.02em;
    line-height: 1.2;
}

p {
    line-height: 1.6;
    color: var(--text-secondary);
}

/* Header Styles */
.app-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: 1.25rem 2.5rem;
    background: rgba(var(--bg-secondary), 0.7);
    backdrop-filter: blur(var(--glass-blur));
    -webkit-backdrop-filter: blur(var(--glass-blur));
    border-bottom: 1px solid var(--border-color);
    position: sticky;
    top: 0;
    z-index: 100;
}

.header-logo {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    font-family: var(--font-heading);
    font-weight: 800;
    font-size: 1.4rem;
    letter-spacing: 0.05em;
    background: linear-gradient(135deg, var(--accent-cyan), var(--accent-purple));
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
}

.DNA-helix-icon {
    font-size: 1.6rem;
    color: var(--accent-cyan);
    background: none;
    -webkit-text-fill-color: initial;
    animation: helix-spin 6s linear infinite;
}

@keyframes helix-spin {
    0% { transform: rotate(0deg); }
    100% { transform: rotate(360deg); }
}

.header-nav {
    display: flex;
    background: var(--bg-tertiary);
    padding: 0.35rem;
    border-radius: 30px;
    border: 1px solid var(--border-color);
    gap: 0.25rem;
}

.nav-btn {
    background: transparent;
    border: none;
    color: var(--text-secondary);
    padding: 0.6rem 1.25rem;
    border-radius: 20px;
    cursor: pointer;
    font-family: var(--font-heading);
    font-weight: 500;
    font-size: 0.95rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
    transition: all var(--transition-fast);
}

.nav-btn:hover {
    color: var(--text-primary);
}

.nav-btn.active {
    background: linear-gradient(135deg, var(--accent-cyan-glow), var(--accent-purple-glow));
    color: var(--accent-cyan);
    border: 1px solid var(--border-hover);
    box-shadow: 0 4px 15px rgba(0, 242, 254, 0.1);
}

.header-theme button {
    background: var(--bg-tertiary);
    border: 1px solid var(--border-color);
    color: var(--text-primary);
    width: 40px;
    height: 40px;
    border-radius: 50%;
    cursor: pointer;
    display: flex;
    align-items: center;
    justify-content: center;
    transition: all var(--transition-fast);
}

.header-theme button:hover {
    border-color: var(--accent-cyan);
    box-shadow: var(--glow-shadow);
}

/* Main Layout */
.app-main {
    flex: 1;
    padding: 2rem 2.5rem;
    max-width: 1400px;
    margin: 0 auto;
    width: 100%;
}

.tab-content {
    display: none;
    animation: fadeIn var(--transition-normal) forwards;
}

.tab-content.active {
    display: block;
}

@keyframes fadeIn {
    from { opacity: 0; transform: translateY(10px); }
    to { opacity: 1; transform: translateY(0); }
}

/* SECTION 1: EXPLORADOR ADN 3D */
.explorador-container {
    display: grid;
    grid-template-columns: 1.6fr 1fr;
    gap: 2rem;
    height: calc(100vh - 200px);
    min-height: 600px;
}

.viewer-3d-wrapper {
    background: var(--bg-secondary);
    border-radius: 24px;
    border: 1px solid var(--border-color);
    position: relative;
    overflow: hidden;
    display: flex;
    flex-direction: column;
    box-shadow: var(--card-shadow);
}

#canvas-container {
    flex: 1;
    width: 100%;
    height: 100%;
    cursor: grab;
}

#canvas-container:active {
    cursor: grabbing;
}

.viewer-controls {
    position: absolute;
    bottom: 1.5rem;
    left: 50%;
    transform: translateX(-50%);
    display: flex;
    gap: 0.75rem;
    background: rgba(19, 26, 38, 0.75);
    backdrop-filter: blur(10px);
    -webkit-backdrop-filter: blur(10px);
    padding: 0.5rem;
    border-radius: 30px;
    border: 1px solid var(--border-color);
    z-index: 10;
}

.ctrl-btn {
    background: transparent;
    border: none;
    color: var(--text-secondary);
    width: 44px;
    height: 44px;
    border-radius: 50%;
    cursor: pointer;
    display: flex;
    align-items: center;
    justify-content: center;
    transition: all var(--transition-fast);
}

.ctrl-btn:hover {
    color: var(--accent-cyan);
    background: rgba(255, 255, 255, 0.05);
}

.ctrl-btn.active {
    background: var(--accent-cyan);
    color: #000;
}

.viewer-legend {
    position: absolute;
    top: 1.5rem;
    left: 1.5rem;
    background: rgba(19, 26, 38, 0.8);
    backdrop-filter: blur(10px);
    -webkit-backdrop-filter: blur(10px);
    border: 1px solid var(--border-color);
    padding: 1rem;
    border-radius: 16px;
    display: flex;
    flex-direction: column;
    gap: 0.5rem;
    z-index: 10;
    pointer-events: none;
}

.legend-item {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    font-size: 0.85rem;
    font-weight: 500;
    color: var(--text-secondary);
}

.legend-dot {
    width: 12px;
    height: 12px;
    border-radius: 50%;
}

.color-A { background-color: var(--color-adenine); box-shadow: 0 0 8px var(--color-adenine); }
.color-T { background-color: var(--color-thymine); box-shadow: 0 0 8px var(--color-thymine); }
.color-G { background-color: var(--color-guanine); box-shadow: 0 0 8px var(--color-guanine); }
.color-C { background-color: var(--color-cytosine); box-shadow: 0 0 8px var(--color-cytosine); }
.color-backbone { background-color: var(--color-backbone); box-shadow: 0 0 8px var(--color-backbone); }
.color-hydrogen { border: 1.5px dashed rgba(255,255,255,0.6); background: transparent; }

/* Info Sidebar & Cards */
.info-sidebar {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
    overflow-y: auto;
    padding-right: 0.5rem;
}

/* Custom Scrollbar for sidebar and boxes */
.info-sidebar::-webkit-scrollbar,
.games-container::-webkit-scrollbar {
    width: 6px;
}
.info-sidebar::-webkit-scrollbar-track,
.games-container::-webkit-scrollbar-track {
    background: transparent;
}
.info-sidebar::-webkit-scrollbar-thumb,
.games-container::-webkit-scrollbar-thumb {
    background: var(--border-color);
    border-radius: 3px;
}

.info-card-container {
    flex: 1;
}

.info-card {
    background: var(--bg-secondary);
    border-radius: 24px;
    border: 1px solid var(--border-color);
    padding: 1.75rem;
    display: flex;
    flex-direction: column;
    height: 100%;
    box-shadow: var(--card-shadow);
    transition: border-color var(--transition-normal);
}

.info-card.selected-element {
    border-color: var(--accent-cyan);
    box-shadow: 0 0 25px rgba(0, 242, 254, 0.08);
}

.card-header {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    margin-bottom: 1.25rem;
    border-bottom: 1px solid var(--border-color);
    padding-bottom: 0.75rem;
}

.header-icon {
    font-size: 1.4rem;
    color: var(--accent-cyan);
}

.info-card h2 {
    font-size: 1.35rem;
    color: var(--text-primary);
}

#info-desc {
    font-size: 0.95rem;
    margin-bottom: 1.5rem;
}

.quick-facts {
    display: flex;
    flex-direction: column;
    gap: 1rem;
}

.fact-box {
    display: flex;
    gap: 0.75rem;
    align-items: flex-start;
    background: var(--bg-tertiary);
    padding: 0.85rem;
    border-radius: 12px;
    border-left: 3px solid var(--accent-purple);
}

.fact-box i {
    color: var(--accent-cyan);
    font-size: 1.1rem;
    margin-top: 0.1rem;
}

.fact-box span {
    font-size: 0.85rem;
    line-height: 1.4;
    color: var(--text-secondary);
}

.card-footer {
    margin-top: auto;
    padding-top: 1.25rem;
    border-top: 1px solid var(--border-color);
}

.helper-text {
    font-size: 0.8rem;
    color: var(--text-muted);
    font-style: italic;
}

/* Mutation Simulator Panel */
.mutation-simulator {
    background: var(--bg-secondary);
    border-radius: 20px;
    border: 1px solid var(--border-color);
    padding: 1.25rem;
    box-shadow: var(--card-shadow);
}

.mutation-simulator h3 {
    font-size: 1rem;
    margin-bottom: 0.5rem;
    color: var(--accent-cyan);
}

.text-small {
    font-size: 0.8rem;
    color: var(--text-secondary);
}

.section-desc {
    margin-bottom: 1rem;
}

.gene-buttons {
    display: grid;
    grid-template-columns: repeat(3, 1fr);
    gap: 0.5rem;
    margin-bottom: 1rem;
}

.gene-btn {
    background: var(--bg-tertiary);
    border: 1px solid var(--border-color);
    color: var(--text-primary);
    padding: 0.6rem 0.4rem;
    border-radius: 8px;
    cursor: pointer;
    font-family: var(--font-heading);
    font-size: 0.85rem;
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: 0.25rem;
    transition: all var(--transition-fast);
}

.gene-btn:hover {
    border-color: var(--accent-purple);
    background: rgba(157, 78, 221, 0.05);
}

.gene-btn.active {
    border-color: var(--accent-cyan);
    background: rgba(0, 242, 254, 0.05);
    box-shadow: var(--glow-shadow);
}

.badge {
    font-size: 0.65rem;
    padding: 0.15rem 0.4rem;
    border-radius: 4px;
    font-weight: 600;
}

.badge.cancer {
    background: rgba(239, 68, 68, 0.15);
    color: var(--danger);
}

.badge.normal {
    background: rgba(16, 185, 129, 0.15);
    color: var(--success);
}

.mutation-feedback-box {
    background: var(--bg-tertiary);
    border: 1px solid rgba(239, 68, 68, 0.2);
    border-radius: 8px;
    padding: 0.75rem;
    animation: slideDown var(--transition-fast) forwards;
}

.mutation-feedback-box.normal-state {
    border-color: rgba(16, 185, 129, 0.2);
}

.mutation-feedback-box h4 {
    font-size: 0.85rem;
    color: var(--danger);
    margin-bottom: 0.25rem;
}

.mutation-feedback-box.normal-state h4 {
    color: var(--success);
}

.mutation-feedback-box p {
    font-size: 0.75rem;
    line-height: 1.3;
}

.hidden {
    display: none !important;
}

@keyframes slideDown {
    from { opacity: 0; transform: translateY(-5px); }
    to { opacity: 1; transform: translateY(0); }
}

/* SECTION 2: TIMELINE */
.section-title {
    font-size: 2.2rem;
    text-align: center;
    margin-bottom: 0.5rem;
    background: linear-gradient(135deg, var(--text-primary), var(--text-secondary));
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
}

.section-subtitle {
    text-align: center;
    color: var(--text-secondary);
    max-width: 600px;
    margin: 0 auto 2.5rem auto;
    font-size: 1rem;
}

.timeline-container {
    display: flex;
    flex-direction: column;
    gap: 2rem;
    background: var(--bg-secondary);
    border-radius: 24px;
    border: 1px solid var(--border-color);
    padding: 2rem;
    box-shadow: var(--card-shadow);
}

.timeline-tabs {
    display: grid;
    grid-template-columns: repeat(4, 1fr);
    gap: 0.75rem;
    border-bottom: 1px solid var(--border-color);
    padding-bottom: 1.5rem;
}

.timeline-tab-btn {
    background: var(--bg-tertiary);
    border: 1px solid var(--border-color);
    color: var(--text-secondary);
    padding: 1rem;
    border-radius: 12px;
    cursor: pointer;
    font-family: var(--font-heading);
    font-weight: 600;
    font-size: 0.95rem;
    display: flex;
    align-items: center;
    gap: 0.75rem;
    transition: all var(--transition-fast);
}

.timeline-tab-btn:hover {
    border-color: var(--accent-purple);
    color: var(--text-primary);
}

.timeline-tab-btn.active {
    background: linear-gradient(135deg, var(--accent-cyan-glow), var(--accent-purple-glow));
    border-color: var(--accent-cyan);
    color: var(--accent-cyan);
}

.step-num {
    background: rgba(255, 255, 255, 0.05);
    width: 28px;
    height: 28px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 0.85rem;
    border: 1px solid var(--border-color);
}

.timeline-tab-btn.active .step-num {
    background: var(--accent-cyan);
    color: #000;
    border-color: var(--accent-cyan);
}

.timeline-content-wrapper {
    min-height: 350px;
}

.timeline-chapter {
    display: none;
    animation: fadeIn var(--transition-normal) forwards;
}

.timeline-chapter.active {
    display: block;
}

.chapter-grid {
    display: grid;
    grid-template-columns: 1.3fr 1fr;
    gap: 2.5rem;
}

.chapter-text h2 {
    font-size: 1.75rem;
    margin-bottom: 1rem;
    color: var(--accent-cyan);
}

.chapter-text p {
    margin-bottom: 1.25rem;
    font-size: 1rem;
}

.highlight-box {
    background: var(--bg-tertiary);
    border-left: 4px solid var(--accent-purple);
    border-radius: 8px;
    padding: 1.25rem;
    margin-top: 1.5rem;
}

.highlight-box h4 {
    margin-bottom: 0.75rem;
    color: var(--text-primary);
}

.highlight-box ul {
    list-style: none;
}

.highlight-box li {
    font-size: 0.9rem;
    margin-bottom: 0.5rem;
    position: relative;
    padding-left: 1.25rem;
    color: var(--text-secondary);
}

.highlight-box li::before {
    content: "•";
    color: var(--accent-cyan);
    font-size: 1.2rem;
    position: absolute;
    left: 0.25rem;
    top: -0.1rem;
}

.chapter-media {
    display: flex;
    justify-content: center;
    align-items: center;
}

.media-frame {
    width: 100%;
    max-width: 380px;
}

/* Polaroid and retro-scientific photos simulation */
.polaroid {
    background: #ffffff;
    padding: 1rem 1rem 2rem 1rem;
    border-radius: 8px;
    box-shadow: 0 10px 25px rgba(0,0,0,0.5);
    transform: rotate(-2deg);
    transition: transform var(--transition-normal);
}

.polaroid:hover {
    transform: rotate(0deg) scale(1.02);
}

.polaroid-img-placeholder {
    width: 100%;
    aspect-ratio: 1;
    background: #f1f5f9;
    border-radius: 4px;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 3.5rem;
    color: #cbd5e1;
    border: 1px solid #e2e8f0;
    position: relative;
}

.polaroid-img {
    width: 100%;
    aspect-ratio: 1;
    object-fit: cover;
    border-radius: 4px;
    display: block;
    border: 1px solid #e2e8f0;
}

.photo-51-polaroid .polaroid-img {
    border-color: rgba(255, 255, 255, 0.1);
}

.dna-drawing-placeholder {
    background: radial-gradient(circle, #e0f2fe 0%, #bae6fd 100%);
    color: #0284c7;
}

.polaroid .caption {
    color: #475569;
    font-family: var(--font-body);
    font-size: 0.8rem;
    text-align: center;
    margin-top: 1rem;
    font-style: italic;
    line-height: 1.3;
}

.photo-51-polaroid {
    background: #111;
    border: 1px solid rgba(255,255,255,0.05);
    transform: rotate(2deg);
}

.photo-51-polaroid .caption {
    color: #94a3b8;
}

.photo-51-sim {
    width: 100%;
    aspect-ratio: 1;
    background: radial-gradient(circle, #222 0%, #050505 100%);
    position: relative;
    border-radius: 4px;
    overflow: hidden;
    display: flex;
    align-items: center;
    justify-content: center;
}

.diffraction-pattern {
    width: 70%;
    height: 70%;
    opacity: 0.7;
    background: 
        radial-gradient(circle, transparent 20%, #ffbe0b 21%, #ffbe0b 23%, transparent 24%, transparent 40%, #ffbe0b 41%, #ffbe0b 43%, transparent 44%),
        repeating-radial-gradient(circle, transparent, transparent 15px, rgba(255,190,11,0.15) 15px, rgba(255,190,11,0.15) 18px);
    mask-image: radial-gradient(circle, black 30%, transparent 70%);
    -webkit-mask-image: radial-gradient(circle, black 30%, transparent 70%);
}

.diffraction-pattern::after {
    content: "X";
    font-size: 6rem;
    font-family: var(--font-heading);
    color: #ffbe0b;
    font-weight: 800;
    opacity: 0.35;
    position: absolute;
    top: 50%;
    left: 50%;
    transform: translate(-50%, -50%) scaleX(1.4);
    filter: blur(1px);
}

/* Chapter 2: Myths vs Facts */
.myths-vs-facts {
    display: flex;
    flex-direction: column;
    gap: 1rem;
    margin: 1.5rem 0;
}

.myths-vs-facts .item {
    display: flex;
    gap: 1rem;
    align-items: flex-start;
    background: var(--bg-tertiary);
    padding: 1rem;
    border-radius: 12px;
    border: 1px solid var(--border-color);
}

.myths-vs-facts .badge {
    flex-shrink: 0;
    font-size: 0.75rem;
    padding: 0.25rem 0.6rem;
    border-radius: 6px;
    font-weight: 700;
    text-transform: uppercase;
}

.badge.myth {
    background: rgba(239, 68, 68, 0.15);
    color: var(--danger);
    border: 1px solid rgba(239, 68, 68, 0.25);
}

.badge.fact {
    background: rgba(16, 185, 129, 0.15);
    color: var(--success);
    border: 1px solid rgba(16, 185, 129, 0.25);
}

.myths-vs-facts p {
    font-size: 0.9rem;
    margin: 0;
    line-height: 1.4;
}

.note-text {
    font-size: 0.85rem;
    color: var(--text-muted);
}

/* Chapter 3: Sequencing steps card layout */
.step-cards {
    display: grid;
    grid-template-columns: repeat(2, 1fr);
    gap: 1.25rem;
    margin-top: 1rem;
}

.step-card {
    background: var(--bg-tertiary);
    border: 1px solid var(--border-color);
    border-radius: 16px;
    padding: 1.25rem;
    display: flex;
    flex-direction: column;
    gap: 0.5rem;
    transition: all var(--transition-fast);
}

.step-card:hover {
    border-color: var(--accent-purple);
    transform: translateY(-2px);
}

.step-badge {
    background: rgba(157, 78, 221, 0.15);
    color: var(--accent-purple);
    font-size: 0.75rem;
    font-weight: 700;
    padding: 0.25rem 0.5rem;
    border-radius: 6px;
    width: fit-content;
}

.step-card h5 {
    font-size: 1rem;
    color: var(--text-primary);
}

.step-card p {
    font-size: 0.85rem;
    margin: 0;
    line-height: 1.4;
}

/* Chapter 4: Database table */
.db-table {
    width: 100%;
    border-collapse: collapse;
    margin: 1.5rem 0;
    background: var(--bg-tertiary);
    border-radius: 12px;
    overflow: hidden;
    border: 1px solid var(--border-color);
}

.db-table th, .db-table td {
    padding: 0.85rem 1.25rem;
    text-align: left;
    font-size: 0.85rem;
}

.db-table th {
    background: rgba(255,255,255,0.03);
    color: var(--accent-cyan);
    font-family: var(--font-heading);
    font-weight: 600;
    border-bottom: 1px solid var(--border-color);
}

.db-table td {
    border-bottom: 1px solid var(--border-color);
    color: var(--text-secondary);
}

.db-table tr:last-child td {
    border-bottom: none;
}

.db-table strong {
    color: var(--text-primary);
}

.clinical-grid {
    display: grid;
    grid-template-columns: repeat(3, 1fr);
    gap: 1.25rem;
    margin-top: 1.5rem;
}

.clinical-item {
    background: rgba(255,255,255,0.02);
    border: 1px solid var(--border-color);
    border-radius: 16px;
    padding: 1.25rem;
    display: flex;
    gap: 1rem;
    align-items: flex-start;
}

.clinical-icon {
    font-size: 1.5rem;
    color: var(--accent-cyan);
    background: var(--bg-tertiary);
    padding: 0.75rem;
    border-radius: 12px;
    border: 1px solid var(--border-color);
}

.clinical-item h5 {
    font-size: 0.95rem;
    margin-bottom: 0.35rem;
}

.clinical-item p {
    font-size: 0.8rem;
    margin: 0;
    line-height: 1.3;
}

/* SECTION 3: GAMES */
.games-nav {
    display: flex;
    justify-content: center;
    gap: 1rem;
    margin-bottom: 2rem;
}

.game-selector-btn {
    background: var(--bg-secondary);
    border: 1px solid var(--border-color);
    color: var(--text-secondary);
    padding: 0.75rem 1.5rem;
    border-radius: 30px;
    cursor: pointer;
    font-family: var(--font-heading);
    font-weight: 600;
    font-size: 0.95rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
    transition: all var(--transition-fast);
    box-shadow: var(--card-shadow);
}

.game-selector-btn:hover {
    color: var(--text-primary);
    border-color: var(--accent-purple);
}

.game-selector-btn.active {
    background: linear-gradient(135deg, var(--accent-cyan), var(--accent-purple));
    color: #000;
    border-color: transparent;
    box-shadow: var(--glow-shadow);
}

.games-container {
    background: var(--bg-secondary);
    border-radius: 24px;
    border: 1px solid var(--border-color);
    padding: 2.5rem;
    min-height: 480px;
    box-shadow: var(--card-shadow);
}

.game-box {
    display: none;
    animation: fadeIn var(--transition-normal) forwards;
}

.game-box.active {
    display: block;
}

/* GAME 1: TRIVIA STYLES */
.quiz-welcome, .quiz-result, .dragdrop-welcome, .dragdrop-result, .flujo-welcome, .flujo-result {
    display: flex;
    flex-direction: column;
    align-items: center;
    text-align: center;
    justify-content: center;
    max-width: 550px;
    margin: 3rem auto;
    gap: 1.25rem;
}

.quiz-icon-lg, .trophy-icon, .success-icon {
    font-size: 4.5rem;
    color: var(--accent-cyan);
    text-shadow: var(--glow-shadow);
    margin-bottom: 0.5rem;
    animation: float-slow 4s ease-in-out infinite;
}

.trophy-icon {
    color: #ffd700;
}

.success-icon {
    color: var(--success);
}

@keyframes float-slow {
    0%, 100% { transform: translateY(0); }
    50% { transform: translateY(-8px); }
}

.action-btn, .action-btn-secondary {
    font-family: var(--font-heading);
    font-weight: 700;
    font-size: 1rem;
    padding: 0.85rem 2rem;
    border-radius: 30px;
    cursor: pointer;
    transition: all var(--transition-fast);
    border: none;
}

.action-btn {
    background: linear-gradient(135deg, var(--accent-cyan), var(--accent-purple));
    color: #000;
    box-shadow: 0 4px 15px rgba(0, 242, 254, 0.2);
}

.action-btn:hover {
    transform: scale(1.03);
    box-shadow: var(--glow-shadow);
}

.action-btn-secondary {
    background: var(--bg-tertiary);
    color: var(--text-primary);
    border: 1px solid var(--border-color);
}

.action-btn-secondary:hover {
    border-color: var(--accent-purple);
    background: rgba(255, 255, 255, 0.03);
}

/* Quiz play screen */
.quiz-header {
    display: flex;
    justify-content: space-between;
    font-family: var(--font-heading);
    font-weight: 600;
    margin-bottom: 0.75rem;
    font-size: 0.9rem;
}

.quiz-score {
    color: var(--accent-cyan);
}

.progress-bar-container {
    background: var(--bg-tertiary);
    height: 8px;
    border-radius: 4px;
    overflow: hidden;
    margin-bottom: 2rem;
    border: 1px solid var(--border-color);
}

.progress-bar-fill {
    background: linear-gradient(90deg, var(--accent-cyan), var(--accent-purple));
    width: 0%;
    height: 100%;
    transition: width var(--transition-normal);
}

.question-text {
    font-size: 1.35rem;
    margin-bottom: 1.5rem;
    font-weight: 600;
}

.options-container {
    display: grid;
    grid-template-columns: repeat(2, 1fr);
    gap: 1rem;
    margin-bottom: 2rem;
}

.option-btn {
    background: var(--bg-tertiary);
    border: 1px solid var(--border-color);
    color: var(--text-primary);
    padding: 1.1rem 1.5rem;
    border-radius: 12px;
    cursor: pointer;
    font-family: var(--font-body);
    font-size: 0.95rem;
    text-align: left;
    transition: all var(--transition-fast);
    display: flex;
    justify-content: space-between;
    align-items: center;
}

.option-btn:hover:not(:disabled) {
    border-color: var(--accent-cyan);
    background: rgba(0, 242, 254, 0.02);
    transform: translateX(3px);
}

.option-btn.correct {
    background: rgba(16, 185, 129, 0.15) !important;
    border-color: var(--success) !important;
    color: var(--success) !important;
    font-weight: 600;
}

.option-btn.wrong {
    background: rgba(239, 68, 68, 0.15) !important;
    border-color: var(--danger) !important;
    color: var(--danger) !important;
}

.quiz-feedback {
    background: var(--bg-tertiary);
    border-radius: 16px;
    border: 1px solid var(--border-color);
    padding: 1.5rem;
    margin-top: 1.5rem;
    display: flex;
    flex-direction: column;
    gap: 0.5rem;
    animation: slideDown var(--transition-fast) forwards;
}

.feedback-text {
    font-family: var(--font-heading);
    font-weight: 700;
    font-size: 1.1rem;
}

.quiz-feedback.correct-feedback {
    border-left: 5px solid var(--success);
}
.quiz-feedback.correct-feedback .feedback-text {
    color: var(--success);
}

.quiz-feedback.wrong-feedback {
    border-left: 5px solid var(--danger);
}
.quiz-feedback.wrong-feedback .feedback-text {
    color: var(--danger);
}

.feedback-explanation {
    font-size: 0.9rem;
    line-height: 1.4;
    margin-bottom: 1rem;
}

.quiz-feedback .action-btn {
    align-self: flex-end;
}

.score-display {
    display: flex;
    align-items: baseline;
    gap: 0.25rem;
    margin: 1rem 0;
}

.final-score {
    font-size: 4rem;
    font-family: var(--font-heading);
    font-weight: 800;
    color: var(--accent-cyan);
    line-height: 1;
}

.total-questions {
    font-size: 1.2rem;
    color: var(--text-secondary);
}

/* GAME 2: DRAG AND DROP ADN BOARD */
.dd-workspace {
    display: flex;
    justify-content: center;
    padding: 2rem 0;
}

.dna-board {
    display: flex;
    gap: 2rem;
    background: rgba(255,255,255,0.01);
    border: 1px solid var(--border-color);
    border-radius: 20px;
    padding: 2rem 3rem;
    align-items: stretch;
}

.dna-side {
    display: flex;
    flex-direction: column;
    gap: 1.25rem;
    width: 140px;
}

.dna-node {
    background: var(--bg-tertiary);
    border: 1px solid var(--border-color);
    padding: 0.85rem;
    border-radius: 10px;
    font-size: 0.85rem;
    font-weight: 600;
    text-align: center;
    user-select: none;
    box-shadow: 0 4px 6px rgba(0,0,0,0.1);
}

/* Coding nodes individually */
.dna-side.left-side-dna .dna-node[data-base="A"] { border-left: 4px solid var(--color-adenine); }
.dna-side.left-side-dna .dna-node[data-base="T"] { border-left: 4px solid var(--color-thymine); }
.dna-side.left-side-dna .dna-node[data-base="G"] { border-left: 4px solid var(--color-guanine); }
.dna-side.left-side-dna .dna-node[data-base="C"] { border-left: 4px solid var(--color-cytosine); }

.dna-connections {
    display: flex;
    flex-direction: column;
    justify-content: space-around;
    align-items: center;
    color: var(--text-muted);
    font-weight: 700;
    font-size: 1.2rem;
    width: 40px;
    letter-spacing: -2px;
}

.h-bond-lines {
    height: 48px;
    display: flex;
    align-items: center;
    user-select: none;
}

.h-bond-lines.double { color: rgba(255, 190, 11, 0.4); }
.h-bond-lines.triple { color: rgba(255, 0, 110, 0.4); }

.dna-slot {
    background: rgba(255, 255, 255, 0.02);
    border: 2px dashed var(--border-color);
    color: var(--text-muted);
    padding: 0.85rem;
    border-radius: 10px;
    font-size: 0.8rem;
    text-align: center;
    display: flex;
    align-items: center;
    justify-content: center;
    transition: all var(--transition-fast);
    height: 48px;
}

.dna-slot.drag-over {
    border-color: var(--accent-cyan);
    background: var(--accent-cyan-glow);
    color: var(--accent-cyan);
}

.dna-slot.correct-dropped {
    border-style: solid;
    border-color: var(--success);
    background: rgba(16, 185, 129, 0.08);
    color: var(--success);
    font-weight: 600;
    animation: popIn 0.3s cubic-bezier(0.175, 0.885, 0.32, 1.275);
}

@keyframes popIn {
    0% { transform: scale(0.9); opacity: 0; }
    100% { transform: scale(1); opacity: 1; }
}

.dd-palette {
    background: var(--bg-tertiary);
    border-radius: 16px;
    border: 1px solid var(--border-color);
    padding: 1.25rem 1.5rem;
    margin-bottom: 1.5rem;
}

.dd-palette h4 {
    font-size: 0.95rem;
    margin-bottom: 0.75rem;
    color: var(--text-secondary);
}

.draggable-bases {
    display: flex;
    gap: 0.75rem;
    justify-content: center;
}

.drag-base {
    width: 48px;
    height: 48px;
    border-radius: 10px;
    display: flex;
    align-items: center;
    justify-content: center;
    font-family: var(--font-heading);
    font-weight: 800;
    font-size: 1.2rem;
    color: #000;
    cursor: grab;
    user-select: none;
    box-shadow: 0 4px 10px rgba(0,0,0,0.35);
    transition: transform var(--transition-fast);
}

.drag-base:active {
    cursor: grabbing;
}

.drag-base:hover {
    transform: translateY(-3px);
}

.drag-base.color-A { background-color: var(--color-adenine); color: #fff; }
.drag-base.color-T { background-color: var(--color-thymine); }
.drag-base.color-G { background-color: var(--color-guanine); color: #fff; }
.drag-base.color-C { background-color: var(--color-cytosine); }

.game-controls {
    display: flex;
    justify-content: center;
    align-items: center;
    flex-direction: column;
    gap: 0.75rem;
}

.game-status-text {
    font-size: 0.95rem;
    font-weight: 600;
}

.game-status-text.success { color: var(--success); }
.game-status-text.error { color: var(--danger); }

/* GAME 3: SORTABLE FLUJO */
.flujo-list {
    display: flex;
    flex-direction: column;
    gap: 0.85rem;
    max-width: 650px;
    margin: 2rem auto;
}

.flujo-item {
    background: var(--bg-tertiary);
    border: 1px solid var(--border-color);
    border-radius: 12px;
    padding: 1rem 1.25rem;
    display: flex;
    align-items: center;
    gap: 1.25rem;
    cursor: grab;
    transition: all var(--transition-fast);
}

.flujo-item:active {
    cursor: grabbing;
}

.flujo-item.dragging {
    opacity: 0.5;
    background: rgba(255,255,255,0.02);
    border-color: var(--accent-purple);
}

.drag-handle {
    color: var(--text-muted);
    font-size: 1.1rem;
    cursor: grab;
}

.flujo-item h5 {
    font-size: 0.95rem;
    color: var(--text-primary);
    margin-bottom: 0.2rem;
}

.flujo-item p {
    font-size: 0.75rem;
}

.flujo-controls {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: 0.75rem;
}

/* Footer */
.app-footer {
    border-top: 1px solid var(--border-color);
    padding: 1.5rem;
    text-align: center;
    font-size: 0.75rem;
    color: var(--text-muted);
    background: rgba(var(--bg-secondary), 0.3);
    margin-top: auto;
}

.app-footer em {
    color: var(--text-secondary);
}

/* Responsive adjustments */
@media (max-width: 1024px) {
    .explorador-container {
        grid-template-columns: 1fr;
        height: auto;
    }
    
    #canvas-container {
        height: 450px;
    }
    
    .timeline-tabs {
        grid-template-columns: repeat(2, 1fr);
    }
    
    .chapter-grid {
        grid-template-columns: 1fr;
    }
    
    .chapter-media {
        order: -1;
        margin-bottom: 1.5rem;
    }
    
    .options-container {
        grid-template-columns: 1fr;
    }
    
    .clinical-grid {
        grid-template-columns: 1fr;
    }
}

@media (max-width: 640px) {
    .app-header {
        flex-direction: column;
        gap: 1rem;
        padding: 1rem;
    }
    
    .timeline-tabs {
        grid-template-columns: 1fr;
    }
    
    .games-nav {
        flex-direction: column;
        align-items: stretch;
    }
}